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There is some online guidance currently available that recommends that MSM taking PrEP can use a dosing schedule where they take a single dose of PrEP on Tuesdays, Thursdays, Saturdays and Sundays, known as ‘the Ts and Ss’. While the motive for simplifying the PrEP dosing schedule is laudable the ASHM PrEP Guidelines Panel does not recommend the ‘Ts and Ss’ dosing schedule as it has not been tested in a clinical trial to demonstrate its efficacy in preventing HIV transmission.