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PrEP can play an important role in preventing HIV infection in people travelling outside of Australia, along with other measures to reduce HIV and STIs (30). If an MSM patient wants to take daily PrEP while on an overseas trip, he can commence two tablets on the day of departure and cease PrEP once it is no longer needed (see section below on ceasing PrEP). Alternatively, the MSM patient can take a double-dose 2-24 hours before sex and then use the on-demand^† regimen outlined above during the overseas trip. Cis - and transgender heterosexual men and women including those who inject drugs who want to take PrEP while on an overseas trip should commence PrEP 7 days before their departure.

^† The Therapeutic Goods Administration (TGA) has not approved this regimen in Australia.