A recent high-risk exposure (within 72 hours)

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A course of non-occupational post exposure prophylaxis (nPEP) may be required if a patient is on daily PrEP, or on-demand^† PrEP and had a recent high-risk exposure (within 72 hours) but only if they did not take PrEP during those days. This nPEP may need to consist of a three-drug regimen, depending on the nature of the exposure. See section on nPEP and PrEP for management of such cases.

^† The Therapeutic Goods Administration (TGA) has not approved this regimen in Australia.