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Patients without HIV infection and with established chronic renal failure, e.g. with estimated glomerular filtration rate (eGFR) that is stably less than 60 mL/min/1.73 m2 should not be prescribed PrEP. The only PrEP regimen proven effective to date and approved by the TGA is TD*/FTC, which is not indicated for those with chronic renal failure (34). However, if a patient with chronic renal failure is at substantial risk of HIV, their condition should be discussed with specialists in the management of HIV and renal disease.